Aktuality | Česká Genetická Banka

25. 02. 2014

NATURE: 20. 2. 2014

"The authors identify pre-leukaemic haematopoietic stem cells (HSCs) in patients with acute myeloid leukaemia; these pre-leukaemic HSCs have the capacity of normal multi-lineage haematopoietic differentiation with a competitive growth advantage over wild-type HSCs, and owing to their persistence may serve as a reservoir for therapeutic resistance and relapse. (...)" více zde >
18. 02. 2014

BLOOD: 13. 2. 2014

"How stem cells interact with the microenvironment to regulate their cell fates and metabolism is largely unknown. Here we demonstrated that the deletion of the cytoskeleton-modulating protein profilin 1 (pfn1) in hematopoietic stem cell (HSCs) led to bone marrow failure, loss of quiescence, and mobilization and apoptosis of HSCs in vivo. (...)" více zde >
10. 02. 2014

BLOOD 6.2.2014

"Gadd45a has been involved in DNA damage response and in many malignancies, including leukemia. However, the function of Gadd45a in hematopoietic stem cells (HSCs) remains unknown. Here, we reported that Gadd45a-deficient (Gadd45a−/−) mice showed a normal hematologic phenotype under homeostatic conditions. (...)" více zde >
03. 02. 2014

BLOOD: 3. 2. 2014

"Increasing evidence supports the importance of cell extrinsic regulation in stem cell fate control. Hematopoietic stem cells (HSC) are responsive to local signals from their niche and to systemic feedback from progenitors and mature cells. (...)" více zde >
27. 01. 2014

NATURE 23.1.2014

"Sexually dimorphic mammalian tissues, including sexual organs and the brain, contain stem cells that are directly or indirectly regulated by sex hormones1, 2, 3, 4, 5, 6. An important question is whether stem cells also exhibit sex differences in physiological function and hormonal regulation in tissues that do not show sex-specific morphological differences. (...)" více zde >
13. 01. 2014

BLOOD: 28. 11. 2013

"CXCR7 is a key actor of the cell cycling and survival promoting effect of CXCL12 on primary human CD34+ HSPCs through Akt signaling." více zde >
09. 01. 2014

BLOOD: 2. 1. 2014

"Hematopoietic stem cells (HSCs) maintain stemness through various mechanisms that protect against stressful conditions. Heat shock proteins (HSPs) preserve cell homeostasis during stress responses through protein quality control, suggesting that HSPs may safeguard HSCs against numerous traumas. (...)" více zde >
27. 12. 2013

SCIENCE: 20.12.2013

In research that Science's editors chose as a runner-up for Breakthrough of the Year, scientists coaxed cells called pluripotent stem cells to grow into tiny "organoids"—liver buds, mini-kidneys, and even rudimentary human brains—in the lab. .. více zde >

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