CELL: Rewind to Recover: Dedifferentiation after Cardiac Injury

In adult mammals, cardiomyocytes are known to reactivate an embryonic gene-expression program after injury. In this issue of Cell Stem Cell, Kubin et al., 2011 show that oncostatin M regulates this dedifferentiation which, while beneficial for recovery from acute injury, if persistent results in heart failure in both rodents and humans.

http://www.cell.com/cell-stem-cell/abstract/S1934-5909(11)00491-7